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Page 1
Nuclear speckle integrity and function require TAO2 kinase.
Gao S, Esparza M, Dehghan I, Aksenova V, Zhang K, Batten K, Ferretti MB, Begg BE, Cagatay T, Shay JW, García-Sastre A, Goldsmith EJ, Chen ZJ, Dasso M, Lynch KW, Cobb MH, Fontoura BMA. Gao S, et al. Proc Natl Acad Sci U S A. 2022 Jun 21;119(25):e2206046119. doi: 10.1073/pnas.2206046119. Epub 2022 Jun 15. Proc Natl Acad Sci U S A. 2022. PMID: 35704758 Free PMC article.
More recently, nuclear speckles have also been implicated in splicing and export of a subset of mRNAs, including the influenza virus M mRNA that encodes proteins required for viral entry, trafficking, and budding. ...Depletion of TAO2 or inhibition of its kinase activity d …
More recently, nuclear speckles have also been implicated in splicing and export of a subset of mRNAs, including the influenza virus M …
Metabolome-wide association study on ABCA7 indicates a role of ceramide metabolism in Alzheimer's disease.
Dehghan A, Pinto RC, Karaman I, Huang J, Durainayagam BR, Ghanbari M, Nazeer A, Zhong Q, Liggi S, Whiley L, Mustafa R, Kivipelto M, Solomon A, Ngandu T, Kanekiyo T, Aikawa T, Radulescu CI, Barnes SJ, Graça G, Chekmeneva E, Camuzeaux S, Lewis MR, Kaluarachchi MR, Ikram MA, Holmes E, Tzoulaki I, Matthews PM, Griffin JL, Elliott P. Dehghan A, et al. Proc Natl Acad Sci U S A. 2022 Oct 25;119(43):e2206083119. doi: 10.1073/pnas.2206083119. Epub 2022 Oct 21. Proc Natl Acad Sci U S A. 2022. PMID: 36269859 Free PMC article.
A novel ultrasensitive and non-enzymatic "turn-on-off" fluorescence nanosensor for direct determination of glucose in the serum: As an alternative approach to the other optical and electrochemical methods.
Dehghan G, Shaghaghi M, Alizadeh P. Dehghan G, et al. Spectrochim Acta A Mol Biomol Spectrosc. 2019 May 5;214:459-468. doi: 10.1016/j.saa.2019.02.054. Epub 2019 Feb 19. Spectrochim Acta A Mol Biomol Spectrosc. 2019. PMID: 30807944
Under the optimum conditions, a linear relationship was obtained between the enhanced fluorescence intensity and glucose concentration in the range of (5-900) 10(-8) M with the detection limit of 1.94 10(-8) M. The proposed sensing system was successfully applied to …
Under the optimum conditions, a linear relationship was obtained between the enhanced fluorescence intensity and glucose concentration in th …
Spectroscopic profiling and computational study of the binding of tschimgine: A natural monoterpene derivative, with calf thymus DNA.
Khajeh MA, Dehghan G, Dastmalchi S, Shaghaghi M, Iranshahi M. Khajeh MA, et al. Spectrochim Acta A Mol Biomol Spectrosc. 2018 Mar 5;192:384-392. doi: 10.1016/j.saa.2017.11.042. Epub 2017 Nov 21. Spectrochim Acta A Mol Biomol Spectrosc. 2018. PMID: 29195192
UV-visible absorption spectrophotometry, fluorescence and circular dichroism (CD) spectroscopies as well as molecular docking study revealed formation of complex between TMG and CT-DNA. Binding constant (K(b)) between TMG and DNA was 2.2710(4)M(-1), that is comparable to g …
UV-visible absorption spectrophotometry, fluorescence and circular dichroism (CD) spectroscopies as well as molecular docking study revealed …
Studies of interaction between terbium(III)-deferasirox and double helix DNA by spectral and electrochemical methods.
Shaghaghi M, Dehghan G, Jouyban A, Sistani P, Arvin M. Shaghaghi M, et al. Spectrochim Acta A Mol Biomol Spectrosc. 2014;120:467-72. doi: 10.1016/j.saa.2013.09.073. Epub 2013 Oct 7. Spectrochim Acta A Mol Biomol Spectrosc. 2014. PMID: 24211806
The binding constants (Kb) for the complex with ctDNA were estimated to be 1.810(4) M(-1) through UV absorption spectrophotometry and fluorescence spectroscopy. ...
The binding constants (Kb) for the complex with ctDNA were estimated to be 1.810(4) M(-1) through UV absorption spectrophotometry and …
Multispectral studies of DNA binding, antioxidant and cytotoxic activities of a new pyranochromene derivative.
Dehkordi MF, Dehghan G, Mahdavi M, Hosseinpour Feizi MA. Dehkordi MF, et al. Spectrochim Acta A Mol Biomol Spectrosc. 2015 Jun 15;145:353-359. doi: 10.1016/j.saa.2015.03.026. Epub 2015 Mar 9. Spectrochim Acta A Mol Biomol Spectrosc. 2015. PMID: 25795609
These results indicated that 3-HC can interact with DNA through non-intercalative mode and the intrinsic binding constant (Kb) for 3-HC with DNA was estimated to be 3.6 10(3)M(-1). The antioxidant activity experiments show that 3-HC also exhibit good antioxidant activity i …
These results indicated that 3-HC can interact with DNA through non-intercalative mode and the intrinsic binding constant (Kb) for 3-HC with …
Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility.
Wessel J, Chu AY, Willems SM, Wang S, Yaghootkar H, Brody JA, Dauriz M, Hivert MF, Raghavan S, Lipovich L, Hidalgo B, Fox K, Huffman JE, An P, Lu Y, Rasmussen-Torvik LJ, Grarup N, Ehm MG, Li L, Baldridge AS, Stančáková A, Abrol R, Besse C, Boland A, Bork-Jensen J, Fornage M, Freitag DF, Garcia ME, Guo X, Hara K, Isaacs A, Jakobsdottir J, Lange LA, Layton JC, Li M, Hua Zhao J, Meidtner K, Morrison AC, Nalls MA, Peters MJ, Sabater-Lleal M, Schurmann C, Silveira A, Smith AV, Southam L, Stoiber MH, Strawbridge RJ, Taylor KD, Varga TV, Allin KH, Amin N, Aponte JL, Aung T, Barbieri C, Bihlmeyer NA, Boehnke M, Bombieri C, Bowden DW, Burns SM, Chen Y, Chen YD, Cheng CY, Correa A, Czajkowski J, Dehghan A, Ehret GB, Eiriksdottir G, Escher SA, Farmaki AE, Frånberg M, Gambaro G, Giulianini F, Goddard WA 3rd, Goel A, Gottesman O, Grove ML, Gustafsson S, Hai Y, Hallmans G, Heo J, Hoffmann P, Ikram MK, Jensen RA, Jørgensen ME, Jørgensen T, Karaleftheri M, Khor CC, Kirkpatrick A, Kraja AT, Kuusisto J, Lange EM, Lee IT, Lee WJ, Leong A, Liao J, Liu C, Liu Y, Lindgren CM, Linneberg A, Malerba G, Mamakou V, Marouli E, Maruthur NM, Matchan A, McKean-Cowdin R, McLeod O, Metcalf GA, Mohlke KL, Muzny DM… See abstract for full author list ➔ Wessel J, et al. Nat Commun. 2015 Jan 29;6:5897. doi: 10.1038/ncomms6897. Nat Commun. 2015. PMID: 25631608 Free PMC article.